Film Productions
| Year | Title | Roles |
|---|---|---|
| 1993 | Ordinary Magic | Jeffrey/Ganesh |
| 1997 | The Alarmist | Howard Ancona |
| 1999 | Coming Soon | Henry Lipschitz |
| Dick | Chip | |
| 2000 | Boltneck | Karl |
| Alive | John | |
| 2001 | Finder’s Fee | Quigley |
| 2002 | National Lampoon’s Van Wilder | Van Wilder |
| Buying the Cow | Mike Hanson | |
| 2003 | The In-Laws | Mark Tobias |
| Foolproof | Kevin | |
| 2004 | Harold & Kumar Go to White Castle | Male nurse |
| Blade: Trinity | Hannibal King | |
| 2005 | The Amityville Horror | George Lutz |
| Waiting… | Monty | |
| Just Friends | Chris Brander | |
| 2006 | Smokin’ Aces | Richard Messner |
| 2007 | The Nines | Gary / Gavin / Gabriel |
| 2008 | Chaos Theory | Frank Allen |
| Definitely, Maybe | Will Hayes | |
| Fireflies in the Garden | Michael | |
| 2009 | Adventureland | Mike Connell |
| X-Men Origins: Wolverine | Wade Wilson / Weapon XI | |
| The Proposal | Andrew Paxton | |
| Paper Man | Captain Excellent | |
| 2010 | Buried | Paul Conroy |
| 2011 | Green Lantern | Hal Jordan / Green Lantern |
| The Change-Up | Mitch Planko | |
| The Whale | Narrator | |
| 2012 | Safe House | Matt Weston |
| Ted | Jared | |
| 2013 | The Croods | Guy |
| Turbo | Turbo | |
| R.I.P.D. | Nick Walker | |
| 2014 | The Voices | Jerry Hickfang, Bosco, Mr. Whiskers, The Deer, and Bunny Monkey |
| The Captive | Matthew | |
| A Million Ways to Die in the West | Cowboy | |
| 2015 | Mississippi Grind | Curtis |
| Woman in Gold | E. Randol Schoenberg | |
| Self/less | Young Damian / Edward | |
| 2016 | Criminal | Bill Pope |
| Deadpool | Wade Wilson / Deadpool | |
| 2017 | No Good Deed | |
| Life | Rory Adams | |
| The Hitman’s Bodyguard | Michael Bryce | |
| 2018 | Deadpool 2 | Wade Wilson / Deadpool |
| Juggernaut | ||
| Himself (cameo) | ||
| 2019 | Great Bear Rainforest | Narrator |
| Detective Pikachu | Detective Pikachu / Harry Goodman | |
| Hobbs & Shaw | Victor Locke (uncredited) Eteon Director |
|
| 6 Underground | One | |
| 2020 | The Croods: A New Age | Guy |
| 2021 | Hitman’s Wife’s Bodyguard | Michael Bryce |
| Deadpool and Korg React | Wade Wilson / Deadpool | |
| Free Guy | Guy | |
| Dude | ||
| Red Notice | Nolan Booth | |
| 2022 | The Adam Project | Adam Reed |
| Bullet Train | Carver | |
| Spirited | Clint Briggs | |
| 2024 | IF  |
TBA |
Television Shows
| Year | Title | Role(s) |
|---|---|---|
| 1990–1993 | Hillside | Billy Simpson |
| 1993–1994 | The Odyssey | Macro / Lee |
| 1994 | My Name is Kate | Kevin Bannister |
| 1995–1998 | The Outer Limits | Paul Nodel / Derek Tillman |
| 1995 | Serving in Silence: The |
Andy |
| 1996 | The X-Files | Jay "Boom" DeBoom |
| The John Larroquette Show | Tony Hemingway | |
| When Friendship Kills | Ben | |
| Sabrina the Teenage Witch | Seth | |
| In Cold Blood | Bobby Rupp | |
| 1998–2001 | Two Guys and a Girl | Michael "Berg" Bergen |
| 2003 | Scrubs | Spence |
| 2004–2005 | Zeroman | Ty Cheese |
| 2005 | School of Life | Michael "Mr. D" D’Angelo |
| 2009 2017 2019 |
Saturday Night Live | Host / Himself |
| 2010 | Sesame Street | Himself |
| 2011, 2012, 2017 | Family Guy | Himself / Overweight Guy |
| 2012 | Top Gear | Himself |
| 2013 | Murder in Manhattan | — |
| 2020 | Jeopardy! The Greatest of All Time | Himself |
| Don’t | Commentator | |
| 2021 | Corner Gas Animated | Himself |
| 2022 | Welcome to Wrexham | Himself |
| 2023 | American Auto | Himself |